abstract::Hydrazone is a bioactive pharmacophore that can be used to design antitumor agents. We synthesised a series of hydrazones (compounds 4-24) incorporating a 4-methylsulfonylbenzene scaffold and analysed their potential antitumor activity. Compounds 6, 9, 16, and 20 had the most antitumor activity with a positive cytotox...
journal_title:Journal of enzyme inhibition and medicinal chemistrypub_type: 杂志文章
doi:10.1080/14756366.2021.1924698
更新日期:2021-12-01 00:00:00
abstract:BACKGROUND:We aimed to investigate the efficacy and tolerability of ultra-hypofractionated radiotherapy (UHRT) in the treatment of low and intermediate-risk prostate cancer patients. METHODS:This retrospective study was conducted using data derived from 44 patients who underwent UHRT, and toxicity assessment and clini...
journal_title:The aging male : the official journal of the International Society for the Study of the Aging Malepub_type: 杂志文章
doi:10.1080/13685538.2021.1948992
更新日期:2021-12-01 00:00:00
abstract::Osteosarcoma (OS) is the most common primary malignant tumor in children and adolescents. Numerous studies have reported the importance of miRNA in OS. The purpose of this study is to predict potential biomarkers and new therapeutic targets for OS diagnosis and prognosis by analyzing miRNAs of OS plasma samples from t...
journal_title:Bioengineeredpub_type: 杂志文章
doi:10.1080/21655979.2021.1947065
更新日期:2021-12-01 00:00:00
abstract::Autophagy is a highly conserved catabolic process which has been implicated in esophageal adenocarcinoma (EAC). We sought to investigate the biological functions and prognostic value of autophagy-related genes (ARGs) in EAC. A total of 21 differentially expressed ARGs were identified between EAC and normal samples. Ge...
journal_title:Bioengineeredpub_type: 杂志文章
doi:10.1080/21655979.2021.1946235
更新日期:2021-12-01 00:00:00
abstract::In this article, we propose high-performance colorimetric detection of Hg+2 using silver nanoprisms. The spherical and triangular AgNPs were synthesized using varied concentration of NaBH4. Pristine AgNPs without any further modification were used for the detection of various metal ions including Hg2+, Pb2+, Cl-, Cd2+...
journal_title:Journal of nanoscience and nanotechnologypub_type: 杂志文章
doi:10.1166/jnn.2021.19529
更新日期:2021-12-01 00:00:00
abstract::This study examined leptin expression in cases of bladder cancer and its diagnostic and prognostic usefulness in bladder malignancies.A set of 128 urinary bladder cancer cases and 24 normal specimens of bladders were employed for an immunohistochemical investigation of leptin expression in tissue microarrays.Leptin wa...
journal_title:The Libyan journal of medicinepub_type: 杂志文章
doi:10.1080/19932820.2021.1949798
更新日期:2021-12-01 00:00:00
abstract::Cerebral infarction (CI) has become a leading cause of death in China. Long non-coding RNAs (lncRNAs) are intensively involved in the progression of CI. Here, we aimed to investigate the effects of lncRNA LOC366613 (LOC366613) on cerebral I/R injury, as well as its possible mechanism. Transient middle cerebral artery ...
journal_title:Bioengineeredpub_type: 杂志文章
doi:10.1080/21655979.2021.1930966
更新日期:2021-12-01 00:00:00
abstract::The present study explored the cooperative effect of both alanine (Ala) and gentamicin (Gent) on metabolic mechanisms by which exogenous Ala potentiates Gent to kill antibiotic-resistant Vibrio alginolyticus. To test this, GC-MS-based metabolomics was used to characterize Ala-, Gent- and both-induced metabolic profile...
journal_title:Virulencepub_type: 杂志文章
doi:10.1080/21505594.2021.1947447
更新日期:2021-12-01 00:00:00
abstract::Expanded graphite and graphite nanosheets were facilely prepared by the thermal expansion of expandable graphite at 800 °C and sand milling of expanded graphite in water, respectively. When the expandable graphite precursor was prepared by the oxidation and intercalation of natural graphite (5 g) using KMnO₄ (6 g) as ...
journal_title:Journal of nanoscience and nanotechnologypub_type: 杂志文章
doi:10.1166/jnn.2021.19516
更新日期:2021-12-01 00:00:00
abstract::Manganese dioxide (α-MnO₂) and graphene oxide (GO nanocomposites were prepared and successfully characterized using Fourier-transform infrared (FT-IR), field emission scanning-electron microscopy (FE-SEM), and energy-dispersive X-ray spectroscopy (EDX) mapping methods and Xray diffraction (XRD) analyses. This reagent ...
journal_title:Journal of nanoscience and nanotechnologypub_type: 杂志文章
doi:10.1166/jnn.2021.19519
更新日期:2021-12-01 00:00:00
abstract::Streptococcus pneumoniae (pneumococcus) is a normal colonizer of the human nasopharynx capable of causing serious invasive disease. Since colonization of the nasopharynx is a prerequisite for progression to invasive diseases, the development of future protein-based vaccines requires an understanding of the intimate in...
journal_title:Virulencepub_type: 杂志文章
doi:10.1080/21505594.2021.1947176
更新日期:2021-12-01 00:00:00
abstract::In this paper we study the Electron Statistics in Heavily Doped N Type-Intrinsic-P Type-Intrinsic structures of non-linear optical, tetragonal and opto-electronic materials in the presence of magnetic quantization. It is found taking such heavily doped structures of Cd₃As₂, CdGeAs₂, InAs, InSb, Hg1-xCdxTe, In1-xGaxAsy...
journal_title:Journal of nanoscience and nanotechnologypub_type: 杂志文章
doi:10.1166/jnn.2021.19539
更新日期:2021-12-01 00:00:00
abstract::In this study, the ruthenium complexes, which is an organometallic N-3 and C-106 semiconductor material, was coated on indium tin oxide (ITO) by using the self-assembled technique and thus a diode containing an organometallic interface was produced. The effects of this interface on the electronic parameters of the dio...
journal_title:Journal of nanoscience and nanotechnologypub_type: 杂志文章
doi:10.1166/jnn.2021.19508
更新日期:2021-12-01 00:00:00
abstract::Synaptotagmins (SYTs), constitute a family of 17 membrane-trafficking protein, palying crucial roles in the development and progression of human cancers. However, only very few studies have investigated the expression profile and prognostic values of SYTs family members in gastric cancer (GC). Therefore, we comprehens...
journal_title:Bioengineeredpub_type: 杂志文章
doi:10.1080/21655979.2021.1951059
更新日期:2021-12-01 00:00:00
abstract::PQQ has anti-inflammatory and anti-oxidant effects. PQQ can relieve high glucose-induced renal cell damage by suppressing Keap1 expression. Keap1 can interact with CUL3. Upregulation of CUL3 facilitates the apoptosis of LPS-induced podocytes. Based on knowledge above, this current work was designed to explore the role...
journal_title:Bioengineeredpub_type: 杂志文章
doi:10.1080/21655979.2021.1935136
更新日期:2021-12-01 00:00:00
abstract::To investigate the effect of miR-149-5p on sphingosine-1-phosphate receptor 2 (S1PR2) expression level and contents of matrix metalloproteinase (MMP-9) and superoxide dismutase (SOD) in the pericytes after acute cerebral ischemia reperfusion in rats, so as to clarify the neuroprotective molecular mechanism induced by ...
journal_title:Bioengineeredpub_type: 杂志文章
doi:10.1080/21655979.2021.1947167
更新日期:2021-12-01 00:00:00
abstract::This study estimated the net macro and micromineral requirement from the 48 male uncastrated lambs (24 growing male Santa Inês and 24 growing male Morada Nova hair sheep), with initial weights of 21.7 ± 1.2 kg and 20.8 ± 0.8 kg using the comparative slaughter method. The experimental diet consisted of 30% forage (Buff...
journal_title:Animal science journal = Nihon chikusan Gakkaihopub_type: 杂志文章
doi:10.1111/asj.13583
更新日期:2021-12-01 00:00:00
abstract:CONTEXT:Schizandrin A (Sch A) is a major phytochemical from Schisandra chinensis (Turcz.) Baill. (Schisandraceae), which exerts a neuroprotective effect in Alzheimer's disease (AD). OBJECTIVE:To investigate the mechanism of Sch A in AD. MATERIALS AND METHODS:AD group: APP/PS1 transgenic mice served as AD models; AD +...
journal_title:Pharmaceutical biologypub_type: 杂志文章
doi:10.1080/13880209.2021.1941132
更新日期:2021-12-01 00:00:00
abstract:BACKGROUND:The purpose of this study was to explore the contribution of each factor of the phosphorus metabolism network following phosphorus diet intervention via Granger causality analysis. METHODS:In this study, a total of six healthy male volunteers were enrolled. All participants sequentially received regular, lo...
journal_title:Renal failurepub_type: 杂志文章
doi:10.1080/0886022X.2021.1945463
更新日期:2021-12-01 00:00:00
abstract::Pulmonary fibrosis (PF) is a chronic pulmonary interstitial disease, and its pathological process is closely related to fibroblast-myofibroblast differentiation. Danshensu (DSS) has been reported to exert an anti-fibrotic effect in heart and liver. However, it is unknown whether DSS has an equally anti-fibrotic effect...
journal_title:Bioengineeredpub_type: 杂志文章
doi:10.1080/21655979.2021.1944020
更新日期:2021-12-01 00:00:00
abstract:OBJECTIVE:Drug-induced acute interstitial nephritis (DAIN) is often associated with improved outcomes, whereas some patients may still progress to chronic kidney disease (CKD). The aim of this study was to evaluate the prognosis of patients with severe DAIN requiring renal replacement therapy (RRT) at baseline, and to ...
journal_title:Renal failurepub_type: 杂志文章
doi:10.1080/0886022X.2021.1942914
更新日期:2021-12-01 00:00:00
abstract:CONTEXT:Recently in Korean medicine, the antioxidant and anti-inflammatory activities of Seonghyangjeongki-san (SHJKS) were reported. However, studies on the specific mechanisms of action of SHJKS for the treatment of ischaemic stroke are still lacking. OBJECTIVE:This study investigates the mechanism of action of the ...
journal_title:Pharmaceutical biologypub_type: 杂志文章
doi:10.1080/13880209.2021.1941130
更新日期:2021-12-01 00:00:00
abstract::Biodegradable microspheres have been widely used in the field of medicine due to their ability to deliver drug molecules of various properties through multiple pathways and their advantages of low dose and low side effects. Poly (lactic-co-glycolic acid) copolymer (PLGA) is one of the most widely used biodegradable ma...
journal_title:Drug deliverypub_type: 杂志文章
doi:10.1080/10717544.2021.1938756
更新日期:2021-12-01 00:00:00
abstract::Primary care providers (PCPs) play an important role in providing medical care for patients with type 2 diabetes. Advancements in diabetes technologies can assist PCPs in providing personalised care that addresses each patient's individual needs. Diabetes technologies fall into two major categories: devices for glycae...
journal_title:Annals of medicinepub_type: 杂志文章
doi:10.1080/07853890.2021.1931427
更新日期:2021-12-01 00:00:00
abstract::Poly(lactic-co-glycolic acid) (PLGA) has garnered increasing attention as a candidate drug delivery polymer owing to its favorable properties, including its excellent biocompatibility, biodegradability, non-toxicity, non-immunogenicity, and mechanical strength. PLAG are specifically used as microspheres for the sustai...
journal_title:Drug deliverypub_type: 杂志文章
doi:10.1080/10717544.2021.1943056
更新日期:2021-12-01 00:00:00
abstract::Aberrant expression of the chemokine CXC receptor 4 (CXCR4) is closely associated with cancer progression and drug-resistance in multiple cancers, and we first investigated the role of CXCR4 in regulating cancer pathogenesis and cisplatin (DDP)-resistance in clear cell renal cell carcinoma (ccRCC) in the present study...
journal_title:Bioengineeredpub_type: 杂志文章
doi:10.1080/21655979.2021.1943112
更新日期:2021-12-01 00:00:00
abstract:Objective:To evaluate the new service model of additional weekend and holiday physiotherapy (PT) by comparing functional outcomes and hospital length of stay between a group of geriatric patients with hip fracture receiving daily PT training and a group of geriatric patients with hip fracture receiving weekdays PT trai...
journal_title:Hong Kong physiotherapy journal : official publication of the Hong Kong Physiotherapy Association Limited = Wu li chih liaopub_type: 杂志文章
doi:10.1142/S1013702521500104
更新日期:2021-12-01 00:00:00
abstract:BACKGROUND:The non-invasive identification of novel renal fibrosis biomarkers needs to be further studied. METHODS:We collected urine samples from 77 biopsy-proven CKD patients and 15 healthy controls. The expression of urinary TREM-1 and TREM-2 was measured and the correlation with renal function parameter and pathol...
journal_title:Annals of medicinepub_type: 杂志文章
doi:10.1080/07853890.2021.1912384
更新日期:2021-12-01 00:00:00
abstract::Osteoarthritis (OA) is a chronic degenerative disease that significantly impacts the quality of life of the elderly population. Recently, the pathogenesis of OA has been reported to involve autophagy in chondrocytes. Intriguingly, icariin, one of the main components of epimedium, exerts multiple pharmacological effect...
journal_title:Bioengineeredpub_type: 杂志文章
doi:10.1080/21655979.2021.1943602
更新日期:2021-12-01 00:00:00
abstract::Five pathways involving different ring structures led to generation of fourteen thienylbenzamides (7-20) which display the structure-activity relationships of class I HDAC inhibitors. All the synthesised compounds inhibit HDAC1 and HDAC2 selectively over other isoforms and many inhibit DLD1 and HCT116 cells more effec...
journal_title:Journal of enzyme inhibition and medicinal chemistrypub_type: 杂志文章
doi:10.1080/14756366.2021.1941920
更新日期:2021-12-01 00:00:00
abstract:OBJECTIVES:Our aim is to investigate the clinical characteristics of low- and intermediate-risk myelodysplastic syndrome (MDS) with pure red cell aplasia (PRCA). METHODS:We retrospectively reviewed the patients of low- and intermediate-risk MDS patients who had been diagnosed with PRCA in our hospital between January ...
journal_title:Hematology (Amsterdam, Netherlands)pub_type: 杂志文章
doi:10.1080/16078454.2021.1929694
更新日期:2021-12-01 00:00:00
abstract::Quercetin (QN) is a naturally occurring phenolic compound found largely in vegetables and fruits. Lycopene (LY) is yet another natural phytocompound, found abundantly in red-colored fruits and vegetables. Both have been reported to have beneficial activities in humans. In this study, we document in vivo experimental m...
journal_title:The Libyan journal of medicinepub_type: 杂志文章
doi:10.1080/19932820.2021.1943924
更新日期:2021-12-01 00:00:00
abstract:OBJECTIVE:To investigate the relationship between preoperative proteinuria and postoperative acute kidney injury (AKI). METHODS:We performed a search on databases included PubMed, Embase, the Cochrane Library, and Web of Science, from December 2009 to September 2020. Data extracted from eligible studies were synthesiz...
journal_title:Renal failurepub_type: 杂志文章
doi:10.1080/0886022X.2021.1940201
更新日期:2021-12-01 00:00:00
abstract:Background:The Internet is increasingly utilized by patients to acquire information about dietary and herbal supplements (DHSs). Previously published studies assessing the quality of websites providing consumer health information about DHSs have been found to contain inaccuracies and misinformation that may compromise ...
journal_title:Integrative medicine researchpub_type: 杂志文章
doi:10.1016/j.imr.2021.100749
更新日期:2021-12-01 00:00:00
abstract:BACKGROUND:Increased levels of microRNA-574-5p (miR-574-5p) have been found to be associated with increased survival of septic patients, indicating the potential role of miR-574-5p in protecting against septic progression and complications. Acute kidney injury (AKI) is one of the most common and serious complications o...
journal_title:Renal failurepub_type: 杂志文章
doi:10.1080/0886022X.2021.1939051
更新日期:2021-12-01 00:00:00
abstract:BACKGROUND:Several European countries face a shortage of general practitioners (GPs), in part due to GP attrition. Most studies of GP attrition have focussed on why GPs decide to leave. Yet understanding why GPs decide to remain may also elicit potential interventions to reduce attrition. OBJECTIVES:This study examine...
journal_title:The European journal of general practicepub_type: 杂志文章
doi:10.1080/13814788.2021.1933938
更新日期:2021-12-01 00:00:00
abstract::Helicobacter pylori infection is linked to serious gastric-related diseases including gastric cancer. However, current therapies for treating H. pylori infection are challenged by the increased antibiotic resistance of H. pylori. Therefore, it is in an urgent need to identify novel targets for drug development against...
journal_title:Virulencepub_type: 杂志文章
doi:10.1080/21505594.2021.1938449
更新日期:2021-12-01 00:00:00
abstract::Low bioavailability of topically applied drugs remains a significant challenge for long-term glaucoma therapy. To enhance drug delivery efficiency, we developed dendrimer gel particles that collectively exhibit structural benefits of dendrimer, hydrogel, and particles, using the inverse emulsion method coupled with th...
journal_title:Chemical engineering journal (Lausanne, Switzerland : 1996)pub_type: 杂志文章
doi:10.1016/j.cej.2021.130498
更新日期:2021-12-01 00:00:00
abstract::The circulation of SARS-CoV-2 has resulted in the emergence of variants of concern (VOCs). It is currently unclear whether the previous infection with SARS-CoV-2 provides protection against reinfection with VOCs. Here, we show that low dose aerosol exposure to hCoV-19/human/USA/WA-CDC-WA1/2020 (WA1, lineage A), result...
journal_title:Emerging microbes & infectionspub_type: 杂志文章
doi:10.1080/22221751.2021.1943539
更新日期:2021-12-01 00:00:00
abstract::Rad51, a DNA-repair-related gene, has been reported to be involved in multiple cancers. However, its link with immune infiltration in liver cancer still unknown. Therefore, more research into the roles and activities of Rad51 in hepatocellular carcinoma (HCC) is required. The International Cancer Genome Consortium (IC...
journal_title:Bioengineeredpub_type: 杂志文章
doi:10.1080/21655979.2021.1938470
更新日期:2021-12-01 00:00:00